A world-wide survey of new data and trends in adverse drug by J.K. Aronson (Eds.)

By J.K. Aronson (Eds.)

Quantity 25 within the sequence http://www.elsevier.com/locate/series/sedaSide results of substances Annuals maintains to serve the target that's set for it: to supply clinicians and scientific investigators with a competent and demanding each year survey of recent information and tendencies within the region of inauspicious Drug Reactions and Interactions. a global staff of experts has reviewed new facts and traits through choosing from the year's writing all that's actually new and informative, by way of significantly analyzing it, and via pointing to no matter what is deceptive. unique beneficial properties of the present annual are an essay through Dr Lara Marks, entitled 'The capsule: untangling the antagonistic results of a drug', important for all staff within the box of Women's health and wellbeing and contraception, and a assessment of the adversarial results of Anthracycline Antibiotics by way of Dr Fraser and Dr Twelves, released as a part of the bankruptcy on 'Cytostatics' through Dr Andrew Stanley. different vital beneficial properties of this Annual are the various precise studies. An index of exact reports is released within the publication. The distinctive reports are brief articles that deal intensive with a selected subject of present curiosity, typographically special from the remainder of the textual content, and marked by means of the prescription image of the attention of Horus. the present Annual is enriched with the notorious 'Drug Index' and 'Index of difficult Drug Reactions'.Side results of substances Annual 25 is the second one replace of the encyclopaedic quantity http://www.elsevier.nl/locate/isbn/0444500936Meyler's unintended effects of substances, Fourteenth variation, which used to be released in 2000.

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There is further evidence, from an uncontrolled observational study in 85 patients, that the dose and duration of administration of fenfluramine-phentermine affects the risk o f Chapter 1 Reginald P. Sequeira significant valvular disease (40~'). The authors suggested that it would be prudent to consider diagnostic echocardiography in patients who have used fenfluramine-phentermine either in a dosage of 60 mg/day or more or f o r 9 months or more. They also raised concerns that f o r patients with mild obesity, the prolonged use of larger cumulative amounts may lead to a higher risk o f valve regurgitation.

The authors suggested that as long as renal function remains stable, low-dose theophylline can be used in transplant patients with erythrocytosis, provided that tacrolimus concentrations are closely monitored. STIMULANT DRUGS (SED-14,12; SEDA-22, 2; SEDA-23, 2; SEDA-24, 2) Amphetamines (SED-14, 16) Nervous system A previously healthy 16-year-old schoolboy had mesencephalic ischemia, most probably caused by vasospasm, after combined abuse of amphetamine and cocaine (9A). There was a close temporal relation between intake of the drug and the onset of symptoms.

Markowitz JS, Morrison SD, De Wane CL. Drug interactions with psychostimulants: a review. Int J Clin Psychopharmacol 1999; 14: 1-18. 31. De Wane CL, Markowitz JS, Carson SW, Boulton DW, Gill HS. Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers. J Clin Psychopharmacol 2000; 20: 347-9. 32. Becker PM, Jamieson AO, Jewel CE, Bogan RK, James DS. Randqmized trial of modafinil as a treatment for the excessive daytime somnolence of nacrolepsy. Neurology 2000; 54:1166-75.

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