Advances in Ocular Toxicology by Keith Green (auth.), Keith Green, Henry F. Edelhauser,

By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

This quantity represents the complaints of the 5th Congress of the foreign Society of Ocular Toxicology (ISOT), which used to be held on the Grove Park lodge and lodge in Asheville, North Carolina, October 13-17, 1996. we're extremely joyful to give this quantity to the ophthalmic neighborhood, specially people with an important curiosity in ocular toxicol­ ogy. The 5th Congress was once built round topics with regards to ocular drug metabolism, the ocular pathophysiological results of nitric oxide, executive matters when it comes to using substitute tools for toxicity trying out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo types in addition to diversified animal types. the result of this congress, embodied during this quantity, is a contribution to the methodologies at present hired or below improvement and to numerous drug or actual results on diversified ocular tissues. whereas the focal point of this court cases is on ocular results of substances or different fabrics, a few of the contributions care for subject matters that experience a wider curiosity. The workshop in regards to the use of other version platforms and the alternative of the easiest animal version for drug trying out covers a variety of pursuits that ex­ has a tendency a ways past particular ocular results. this is often very true within the quarter of other equipment and within the collection of the easiest animal version for exam of other ailment entities.

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Reddy and Han l5 used a more sensitive amino acid analyzer to quantify the released GSH. All these methods suffer from the risk of auto-oxidation of the released thiols as well as possible incomplete removal of added NaBH4 or thiol protecting agents. To circumvent the above shortcomings we have developed a new method by using a strong oxidant (performic acid) to treat the lens homogenate, thereby opening the disulfide bridges and releasing the non-protein thiols as stable sulfonic acid products.

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