Advances in Ocular Toxicology by Keith Green (auth.), Keith Green, Henry F. Edelhauser,

By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

This quantity represents the complaints of the 5th Congress of the foreign Society of Ocular Toxicology (ISOT), which used to be held on the Grove Park lodge and lodge in Asheville, North Carolina, October 13-17, 1996. we're extremely joyful to give this quantity to the ophthalmic neighborhood, specially people with an important curiosity in ocular toxicol­ ogy. The 5th Congress was once built round topics with regards to ocular drug metabolism, the ocular pathophysiological results of nitric oxide, executive matters when it comes to using substitute tools for toxicity trying out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo types in addition to diversified animal types. the result of this congress, embodied during this quantity, is a contribution to the methodologies at present hired or below improvement and to numerous drug or actual results on diversified ocular tissues. whereas the focal point of this court cases is on ocular results of substances or different fabrics, a few of the contributions care for subject matters that experience a wider curiosity. The workshop in regards to the use of other version platforms and the alternative of the easiest animal version for drug trying out covers a variety of pursuits that ex­ has a tendency a ways past particular ocular results. this is often very true within the quarter of other equipment and within the collection of the easiest animal version for exam of other ailment entities.

Show description

Read or Download Advances in Ocular Toxicology PDF

Best toxicology books

Ototoxicity

'Ototoxicity' is a compendium of knowledge at the ototoxic strength of clinically worthwhile medications. every one element of this thorough textual content is written by means of a number one authority within the box. The ebook reports the real periods of medicines recognized to reason ototoxicity and their mechanisms. scientific manifestations, what's recognized approximately pathophysiology, thoughts for prevention and therapy, and medical-legal concerns for every category of compounds are reviewed.

Professional's Handbook of Financial Risk Management

The Professional's guide of economic hazard administration is a big reference paintings in finance. an entire useful reference publication protecting all points of economic probability administration together with an in-depth examine operational possibility administration, rules, risk-based capital, and chance adjusted functionality dimension.

Extra info for Advances in Ocular Toxicology

Sample text

Reddy and Han l5 used a more sensitive amino acid analyzer to quantify the released GSH. All these methods suffer from the risk of auto-oxidation of the released thiols as well as possible incomplete removal of added NaBH4 or thiol protecting agents. To circumvent the above shortcomings we have developed a new method by using a strong oxidant (performic acid) to treat the lens homogenate, thereby opening the disulfide bridges and releasing the non-protein thiols as stable sulfonic acid products.

Int J Biochem 1988; 20:543-588. 123. Schwartzman ML, Abraham NG, Carroll MA, Levere RD, McGiff Jc. Regulation of arachidonic acid metabolism by cytochrome P450 in rabbit kidney. Biochem J 1986; 238:283-290. 124. Sacerdoti D, Escalante B, Abraham NG, McGiff JC, Levere RD, Schwartzman ML. Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats. Science 1989; 243:388--390. 125. Kappas A, Maines MD. Tin: a potent inducer of heme oxygenase in kidney. Science 1976; 192:60-62.

93. Krupin T, Becker B, Podos SM. Topical vanadate lowers intraocular pressure in rabbits. Invest Ophthalmol Vis Sci 1980; 19:360-1366. 94. DeSousa RC, Grosso A. Vanadate blocks cyclic AMP-induced stimulation of sodium and water transport in amphibian epithelia. Nature 1979; 279:803. Cytochrome P4S0 and Arachidonic Acid Metabolism in the Corneal Epithelium 19 95. Crawford K, Kaufinan PL. Pilocarpine antagonizes prostaglandin F2-induced ocular hypotension in monkeys. Arch Ophthalmol1987; 105:1112.

Download PDF sample

Rated 4.84 of 5 – based on 7 votes