By David A. Gewirtz, Shawn E. Holt, Steven Grant
This e-book offers perception into demonstrated practices and study into apoptosis and senescence. the amount completely examines novel and rising recommendations and study within the fields of cellphone demise pathways, senescence development arrest, medications and resistance, DNA harm reaction, and different subject matters that also carry mysteries for researchers. In overall, this quantity presents easy scientists and clinicians with a deeper and extra entire knowing of the mobile responses of malignancies which could make sure the effectiveness of remedy, either within the preliminary levels of the disorder in addition to in illness recurrence.
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Extra resources for Apoptosis, Senescence and Cancer
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Moving further downstream, silencing of APAF-1 has been reported in a large fraction of melanoma cell lines and clinical samples (280). Consistent with prior observations in Apaf -1−/− murine fibroblasts and thymocytes (281), the Apaf-1-deficient melanoma cells were reportedly resistant to doxorubicin-induced apoptosis (280). Although the authors concluded that they had identified a major mechanism of drug resistance in melanoma, subsequent observations have called this conclusion into question.
Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 1995; 182(5):1545–56. 43. Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002; 417:182–7. 44. Hanayama R, Tanaka M, Miyasaka K, et al. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice.