Apoptosis, Senescence and Cancer by David A. Gewirtz, Shawn E. Holt, Steven Grant

By David A. Gewirtz, Shawn E. Holt, Steven Grant

This e-book offers perception into demonstrated practices and study into apoptosis and senescence. the amount completely examines novel and rising recommendations and study within the fields of cellphone demise pathways, senescence development arrest, medications and resistance, DNA harm reaction, and different subject matters that also carry mysteries for researchers. In overall, this quantity presents easy scientists and clinicians with a deeper and extra entire knowing of the mobile responses of malignancies which could make sure the effectiveness of remedy, either within the preliminary levels of the disorder in addition to in illness recurrence.

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Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1998; 335(6189):440–2. 76. Hockenbery DM, Nuñez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990; 348:334–6. 77. Puthalakath H, Strasser A. Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ 2002; 9:505–12.

Moving further downstream, silencing of APAF-1 has been reported in a large fraction of melanoma cell lines and clinical samples (280). Consistent with prior observations in Apaf -1−/− murine fibroblasts and thymocytes (281), the Apaf-1-deficient melanoma cells were reportedly resistant to doxorubicin-induced apoptosis (280). Although the authors concluded that they had identified a major mechanism of drug resistance in melanoma, subsequent observations have called this conclusion into question.

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 1995; 182(5):1545–56. 43. Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002; 417:182–7. 44. Hanayama R, Tanaka M, Miyasaka K, et al. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice.

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