By C. Gopinath, D. Prentice, D.J. Lewis
Our goal in generating a color atlas of toxicological instructions itemize the investigations to be conducted pathology was once to give a listing of histopathologi through the process the examine and so they typically comprise: cal lesions which we had encountered through the years in scientific observations and behavior; meals consumption and physique a variety of laboratory animal species uncovered to an enormous weight measurements; serum biochemistry; haema diversity of prescription drugs, agrochemicals and business tology; ECG and ophthalmology. on the finish of a research, chemical compounds. whereas we think a color atlas is the suitable complete macroscopic and microscopic examinations of ways to percentage our stories with others, it fast organ weight analyses including tissues are essen grew to become transparent to us that for the atlas to be significant tial. through a long way the higher a part of the fabric utilized in this the linked textual content has to be finished and include e-book is from toxicity experiences performed in recent times abundant literature references. and played in compliance with the great Laboratory The atlas is meant for either the trainee and the perform criteria of governmental regulatory our bodies in skilled toxicological pathologist operating with lab Europe, Japan and North the US. oratory animals within the pharmaceutical, agrochemical or Toxicity stories are usually conducted in rats, chemical environment.
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And Klingberg, M. A. (eds) Air Pollution and the Lung. pp. 253-267. (New York: Wiley) 21. Sturgess, J. and Reid, L. (1973). The effect of isoprenaline and pilocarpine on (a) bronchial mucus-secreting tissue and (b) pancreas, salivary glands, heart, thymus, liver and spleen. Br. J. Exp. , 54, 388-402 22. Jeffery, P. K. and Reid, L. M. (1977). The respiratory mucous membrane. In Brain, J. , Proctor, D. F. and Reid, L. M. (eds) Respiratory Defense Mechanisms. pp. 193-245. (New York: Marcel Dekker) 23.
Effect of cholesterol feeding in rat reticuloendothelial system. Arch. , 72, 78-88 56. , Fink, L. M. and Virmani. R. (1984). Perfluorochemicals. Arch. Pathol. Lab. , 108, 631-637 57. Leslie, G. , Noakes, D. , Pollitt, F. , Roe, F. J. C. and Walker, T. F. (1981). A two-year study with cimetidine in the rat: assessment for chronic toxicity and carcinogenicity. Toxicol. Appl. , 61, 119-137 58. van Haeringen, J. , Hilvering, C. and Sluiter, H. J. (1972). Diseases of the respiratory tract due to drugs.
Pulmonary emphysema is 'a condition characterized by abnormal, permanent enlargement of air spaces distal to the terminal bronchioles accompanied by destruction of their walls and without obvious fibrosis'52. It is rarely produced in laboratory animals during inhalation toxicity studies, although N0 2 , cadmium chloride aerosol, hexane and also some lathyritic agents such as j3-aminopropionitrile, when given to rapidly growing animals are reported to produce positive results 52 . ,.. t . 1 ~. 73 Phospholipidosis induced in a rat lung by a cationic amphiphilic drug.